The Science Behind TrueSelf™
There is an ever-growing body of evidence which demonstrates that a diet low in certain sugars – fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (“FODMAPs”) – can provide meaningful relief to those with gastrointestinal discomfort.
Dr. O’Brien discovered that despite all the benefits of a low FODMAP diet, compliance is difficult because many common foods and ingredients contain high levels of FODMAPs.
Low FODMAP Clinical Research
The low FODMAP diet was born out of research pioneered by a team of physicians, nutrition scientists and dietitians at the Monash University in Australia over the last decade.
There is a large (and growing!) body of evidence published in rigorous scientific journals supporting the use of a diet lower in FODMAPs in alleviating digestive discomfort.
Sample of Clinical Studies/Scientific Literature:
In a controlled, cross-over study of patients with IBS, a diet low in FODMAPs effectively reduced functional gastrointestinal symptoms. This high-quality evidence supports its use as a first-line therapy.
A Diet Low in FODMAPs Reduces Symptoms of Irritable Bowel Syndrome.
Halmos, EP et al., Gastroenterology 2014; 146:67-75.
In patients with irritable bowel syndrome, there is now an accumulating body of evidence, based on observational and comparative studies, and on randomized-controlled trials that supports the notion that FODMAPs trigger gastrointestinal symptoms in patients with functional bowel disorders, and that a diet low in FODMAPs offers considerable symptom relief in the majority of patients who use it.
Short Chain Carbohydrates and Functional Gastrointestinal Disorders.
Shepherd, S, et al., Am J Gastroenterology 2013; 108:707-717.
Symptoms of abdominal pain, bloating, flatulence and diarrhea significantly improved in patients adherent to a low FODMAP diet.
The Low FODMAP Diet Improves Gastrointestinal Symptoms in Patients with Irritable Bowel Syndrome.
de Roest RH, et al., Int J Clin Pract 2013; 67 (9): 895-903.
Six randomized controlled trials and 16 non-randomized interventions were included in a analysis of the scientific literature on the low FODMAP diet, published through March 2015, which supports the efficacy of a low FODMAP diet in the treatment of functional gastrointestinal symptoms.
Does a diet low in FODMAPs reduce symptoms associated with functional gastrointestinal disorders? A comprehensive systematic review and meta-analysis.
Marsh, A, et al., European J Nutrition 2015; [Epub ahead of print]
FODMAPS are poorly absorbed molecules that are are rapidly fermented to produce gas or draw water to distend the intestines, causing pain, bloat, gas and change in bowel motility.
Clinical Ramifications of Malabsorption of Fructose and Other Short-chain Carbohydrates
Barrett J, et al., Pract Gastroenterology 2007; 31:51-65.
Fructose distends the small bowel with water. Adding glucose to fructose reduces the effect of fructose on small bowel water content. Inulin, which is a fructan, distends the colon with gas more than fructose, but causes few symptoms in healthy volunteers.
Differential Effects of FODMAPs (Fermentable Oligo-, Di-, Mono-Saccharides and Polyols) on Small and
Large Intestinal Contents in Healthy Subjects Shown by MRI
Murry, K et al., Am J Gastroenterology 2014; 109:110–119.
Dietary FODMAPs induce prolonged hydrogen production in the intestine that is greater in IBS, influence the amount of methane produced, and induce gastrointestinal and systemic symptoms experienced by patients with IBS.
Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome.
Ong, D, et al., Journal of Gastroenterology and Hepatology 2010; 25; 1366-1373.